Indometh {datasets} | R Documentation |
The Indometh
data frame has 66 rows and 3 columns of data on
the pharmacokinetics of indomethicin.
Indometh
This data frame contains the following columns:
an ordered factor with containing the subject codes. The ordering is according to increasing maximum response.
a numeric vector of times at which blood samples were drawn (hr).
a numeric vector of plasma concentrations of indomethicin (mcg/ml).
Each of the six subjects were given an intravenous injection of indomethicin.
Kwan, Breault, Umbenhauer, McMahon and Duggan (1976), Kinetics of Indomethicin absorption, elimination, and enterohepatic circulation in man. Journal of Pharmacokinetics and Biopharmaceutics, 4, 255–280.
Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for Repeated Measurement Data, Chapman & Hall (section 5.2.4, p. 134)
Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer.
require(stats)
fm1 <- nls(conc ~ SSbiexp(time, A1, lrc1, A2, lrc2),
data = Indometh, subset = Subject == 1)
summary(fm1)